A 32-year-old female presented with a 3-month history of persistent low mood, anhedonia, fatigue, early morning awakening, and decreased appetite. She denied suicidal ideation. Mental status exam revealed flat affect and psychomotor retardation. PHQ-9 score was 18, consistent with moderate depression. She was started on Sertraline 50 mg once daily, with counseling on potential side effects. She was referred for cognitive-behavioral therapy and encouraged to engage in regular exercise and sleep hygiene. A follow-up appointment was scheduled in 2 weeks to assess response and side effects.